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KMID : 0043319910140040285
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Archives of Pharmacal Research
1991 Volume.14 No. 4 p.285 ~ p.289
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Spectrophotometric Determination of Amantadine Sulfate after Ion-Pairing with Methyl Orange
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Choi K
Choi JK/Yoo GS
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Abstract
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A convenient spectrophotometric method was examined for the determination of amantadine sulfate (AMTS) which has no UV-VIS chromopohores. AMTS was ionpaired quantitatively with methyl orange (MO) at 70oC for 30 min. The ion-paired complex was extracted with dichloromethane and the absorbance was measured at 421.5 nm. A linear relationship was observed in the range of 2.5 X 1O-7M to 3.75 X 1O-6M and the correlation coefficient was 0.999 (n=3). This assay method was applied to the quantification of AMTS in commercial tablet from with good recovery and high precision.
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KEYWORD
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